Hyperhomocysteinemia: Risk Factors and Faster Onset of Degenerative Complications of Type 2 Diabetes in Brazzaville

Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Among the biochemical markers associated with increased risk for disease, homocysteine is currently one predictive under evaluation. We investigate link between hyperhomocysteinemia and complications DT2 population Brazzaville. Methodology: conducted cross-sectional analytical study, from October December 2022. One hundred fifty participants were included, 100 patients T2D (34 33 comorbidities, without), 50 controls. Sociodemographic clinical characteristics collected. Homocysteine (Hcy) serum levels measured using Sandwich ELISA method. Results: Study was composed 50% males females sex ratio 1; mean age 52.2 ± 10.8 years (30 - 83). The prevalence (HHcy) 36% (20% moderate Hcy, 15% intermediate 1% severe). Mean Hcy concentration 31.9 μmol/l (18 103). Age, gender physical inactivity strongly correlated (OR 3.5; 9.4 3 respectively). Multivariate analysis showed that HHcy accelerator degenerative (stroke: OR = 6.2; ischemic heart disease: 4.9; neuropathy: 9.2; retinopathy: 4.5 peripheral arterial 4.9). Conclusion: These findings suggest be considered as marker taken into account targeting Congolese subjects